SYN-AKE Peptide Mask

What is SYN®-AKE?

SYN®-AKE is a biomimetic tripeptide developed by Pentapharm (now part of Lipotec/Lubrizol), designed to replicate the muscle-relaxing action of Waglerin-1, a peptide found in the venom of the Temple Viper (Tropidolaemus wagleri). Unlike injectable neuromodulators, SYN®-AKE works topically by competing with acetylcholine at the neuromuscular junction, temporarily relaxing the small facial muscles responsible for expression lines. This mechanism is why SYN®-AKE is often referred to in the industry as a "topical alternative to Botox" – it offers a non-invasive way to visibly soften expression lines without injections.

Main Benefits:

• Moisturizing and hydrating
• Brighten tone
• Smooth lines
• Reduce wrinkles
• Soften texture

Key Ingredients:

• SYN®-AKE: SYN®-AKE is a small synthetic peptide that helps reduce the appearance of wrinkles and laugh lines—fast. As our skin gets older, so do the number of expression and laughter lines, along with crow’s feet and forehead wrinkles. SYN®-AKE enables the face to relax, reducing wrinkles but without losing the ability to help people express themselves. It’s fast-acting, long-lasting, and fully reversible.
• D-Panthenol (Pro-Vitamin B5): D-Panthenol is a versatile and effective ingredient in skincare, offering deep hydration, soothing effects, and enhanced skin healing. Its ability to improve skin barrier function and elasticity makes it a valuable addition to many skincare routines.
• Hydrolyzed Collagen: Hydrolyzed collagen offers a multifaceted approach to skincare, addressing hydration, elasticity, and overall skin health. Whether used in topical formulations or taken as a supplement, it can be a valuable addition to your skincare routine.
• Sodium Hyaluronate: Sodium hyaluronate is a powerhouse ingredient in skincare, offering deep hydration, improved texture, and anti-aging benefits. Its ability to penetrate the skin and deliver lasting moisture makes it a valuable addition to any skincare routine.
• Aloe vera extract: Aloe Vera has powerful anti-inflammatory properties that help soothe and calm irritated skin. It's particularly beneficial for sunburn, redness, and minor burns, providing immediate relief and cooling effect.
• Allantoin: Derived from comfrey, it has moisturizing and calming effects, and can effectively soften cuticles and relieve redness, swelling, and skin discomfort.
• 3-o-ethyl ascorbic acid: Unlike traditional vitamin C (L-ascorbic acid), 3-o-ethyl ascorbic acid is highly stable, ensuring it remains potent and effective over time. It can effectively reduce hyperpigmentation, dark spots, and uneven skin tone, revealing a brighter and more radiant complexion.

Why a Sheet Mask Format for SYN®-AKE?

A sheet mask format allows SYN®-AKE and the accompanying active complex to stay in close contact with the skin for an extended period, which supports better absorption compared to a quick leave-on application. This makes the mask format especially suitable for intensive, occasional-use positioning – such as a pre-event treatment or a weekly anti-wrinkle ritual – rather than a daily leave-on product. Brands building an anti-aging or "express facial" product line often pair a SYN®-AKE sheet mask with a complementary serum or cream from the same active system.

Frequently Asked Questions

What is SYN®-AKE peptide made of?
SYN®-AKE is a synthetic tripeptide manufactured to mimic the action of Waglerin-1, a compound found in Temple Viper venom. No actual snake venom is used in the ingredient – it is produced through peptide synthesis in a controlled laboratory environment.

Is SYN®-AKE safe for topical use?
Yes. SYN®-AKE is widely used in commercial skincare formulations and is considered safe for topical application at standard cosmetic use levels. As with any active ingredient, a patch test is recommended for sensitive skin.

How is SYN®-AKE different from Botox?
Botox is an injectable neurotoxin that blocks nerve signals to muscles. SYN®-AKE is a topical ingredient that works on the skin's surface to relax the look of expression lines through a different, non-injectable mechanism. The two are not interchangeable in mechanism or regulatory classification, but SYN®-AKE is commonly marketed as a non-invasive alternative for softening the appearance of expression lines.

Can Fermic customize the SYN®-AKE concentration or formula?
Yes. As your OEM/ODM partner, Fermic can adjust the SYN®-AKE concentration, pair it with complementary actives, and customize the mask sheet material to match your brand's positioning and price point. Contact us to discuss your formulation requirements.

OEM/ODM Private Label Service:

We not only provide private labeled products, but we also design and develop products according to customers' needs.

Formula, fragrance, active ingredients, and more can be designed according to the customer’s needs